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Doxazosin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Doxazosin图片
CAS NO:74191-85-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
多沙唑嗪
UK 33274
产品介绍
Doxazosin (UK 33274) 能选择性拮抗突触后的α1肾上腺素受体。
生物活性

Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynapticα1-adrenergic receptors.

IC50& Target

α1-adrenergic receptors[1]

体外研究
(In Vitro)

Doxazosin(UK 33274) is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms[1]. doxazosin may have a direct inhibitory effect on cholesterol synthesis independent of the LDL receptor. The inhibition of cholesterol synthesis by doxazosin may cause cells to compensate by upregulating the LDL receptor, thereby increasing the importation of lipoprotein cholesterol and reducing LDL cholesterol in the medium[2]. Doxazosin monotherapy was effective in eight of 12 patients (66.7%), and combined therapy with a beta-blocker was effective in 11 of 12 patients (91.7%). The mean pulse rate remained constant throughout therapy. Adverse reactions were minor and transient and occurred in only three patients. Urinary and plasma catecholamine levels tended to decrease or remained unchanged during doxazosin therapy[3].

Clinical Trial
分子量

451.48

Formula

C23H25N5O5

CAS 号

74191-85-8

中文名称

多沙唑嗪

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.