CAS NO: | 109351-33-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | (S)-Terazosin is an active S-enantiomer of Terazosin. (S)-Terazosin is a potent and high-affinityα-adrenoceptorantagonist withKivalues of 3.91 nM, 0.79 nM and 1.16 nM forα1a,α1bandα1d-adrenoceptor, respectively. (S)-Terazosin also has high-affinity forα2a,α2Bandα2c-adrenoceptor withKivalues of 729 nM, 3.5 nM and 46.4 nM, respectively[1]. | ||||||||||||||||
IC50& Target | Ki: 3.91 nM (α1a-adrenoceptor), 0.79 nM (α1b-adrenoceptor) and 1.16 nM (α1d-adrenoceptor); 729 nM (α2a-adrenoceptor), 3.5 nM (α2Ba-adrenoceptor) and 46.4 nM (α2c-adrenoceptor)[1] | ||||||||||||||||
体外研究 (In Vitro) | The racemic compound and its enantiomers show high and apparently equal affinity for subtypes of α1-adrenoceptors with Kivalues in the low nanomolar range, and showed potent antagonism of α1-adrenoceptors in isolated tissues, with the enantiomers approximately equipotent to the racemate at each α1-adrenoceptor subtype. At α2b sites, (R)-Terazosin binds less potently than either the (S)-Terazosin or racemate[1]. | ||||||||||||||||
体内研究 (In Vivo) | (S)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC30 of 6.93. (s)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA2 values of 8.3 and 6.12, respectively[1]. | ||||||||||||||||
分子量 | 387.43 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C19H25N5O4 | ||||||||||||||||
CAS 号 | 109351-33-9 | ||||||||||||||||
中文名称 | (S)-特拉唑嗪 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 150 mg/mL(387.17 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |