Rauwolscine hydrochloride is a potent and specificα2 adrenergicreceptor antagonist with aK_iof 12 nM.

Ki: 12 nM (α2 adrenergic receptor)^[1]

[³H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [³H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes^[1]. [³H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors^[2]. When using [³H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (K_ihuman=14.3 nM, K_irat=35.8 nM)^[3]. Saturation studies shows that the affinity of [³H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM)^[4].

390.90

Solid

C₂₁H₂₇ClN₂O₃

6211-32-1

萝芙素；育亨宾碱；洛芙素盐酸盐；萝芙素盐酸盐

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Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

DMSO : 6 mg/mL(15.35 mM;Need ultrasonic)

H₂O : 5 mg/mL(12.79 mM;Need ultrasonic)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。