您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Dobutamine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Dobutamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dobutamine图片
CAS NO:34368-04-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
多巴酚丁胺;杜丁胺
产品介绍
Dobutamine 是合成的儿茶酚胺,作用于肾上腺素能受体α1-AR,β1-ARβ2-AR。Dobutamine 是一种选择性的 β1-AR 受体激动剂,对 α1-AR 和 β2-AR 作用相对较弱。Dobutamine 可增加心输出量,矫正低灌注。
生物活性

Dobutamine is a synthetic catecholamine that acts onα1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4].

体内研究
(In Vivo)

Dobutamine has a rapid onset of action and a short half-life[2].
Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3].
Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3].
Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3].
Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3].
Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4].

Animal Model:Tgαq*44 mice (heart failure models)[3]
Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:Intraperitoneal injection
Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.
Clinical Trial
分子量

301.38

Formula

C18H23NO3

CAS 号

34368-04-2

中文名称

多巴酚丁胺;杜丁胺

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.