Pronethalol ((±)-Pronethalo) is a non-selectiveβ-adrenergicantagonist. Pronethalol is a potent inhibitor ofSox2expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)^[1][2].

Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment^[2].

Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) inMgp^–/–mice^[2].

265.78

C₁₅H₂₀ClNO

51-02-5

盐酸普罗纳赛洛；盐酸丙萘洛尔

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.