您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Lumateperone
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Lumateperone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lumateperone图片
CAS NO:313368-91-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
ITI-007
产品介绍
Lumateperone (ITI-007) 是一种5-HT2A受体拮抗剂 (Ki = 0.54 nM)、突触前 D2 受体的部分激动剂和突触后 D2 受体的拮抗剂 (Ki = 32 nM)、多巴胺 D1 受体调节剂。Lumateperone 具有抗癌活性, 可用于精神分裂症等相关精神病的研究。
生物活性

Lumateperone (ITI-007) is a5-HT2Areceptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator. Lumateperone has anticancer activity and can also be used in studies of psychiatric disorders such as schizophrenia[1][2][3].

体外研究
(In Vitro)

Lumateperone (2-30 μM) has anti-tumor activity and can inhibit cell proliferation in a dose-dependent manner[1].

Cell Proliferation Assay[1]

Cell Line:RPMI-8226 cells
Concentration:2-30 μM
Incubation Time:48 hours
Result:Inhibited cell growth with the IC50value of 17.30 μM.
体内研究
(In Vivo)

Lumateperone (i.p., 1-10 mg/kg) promotes NMDA and AMPA-induced currents in a dopamine D1 receptor-dependent manner and increases the release of dopamine and glutamate in rat mPFC slices[2].

Animal Model:Adult male Sprague-Dawley rats[2]
Dosage:1-10 mg/kg
Administration:Intraperitoneal injection
Result:Inhibited avoidance response at concentrations of 1, 3 and 10 mg/kg after 20 minutes.
Promoted NMDA and AMPA-sensitive currents, also significantly increased dopamine and glutamate release at 10 mg/kg in mPFC cone cells of rat.
Clinical Trial
分子量

393.50

Formula

C24H28FN3O

CAS 号

313368-91-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.