SIRT1/2/3-IN-1

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SIRT1/2/3-IN-1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2413212-06-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

SIRT1/2/3-IN-1 (compound 10) 是一种高效的，选择性的和细胞渗性的 SIRT1/2/3 抑制剂，抑制SIRT1，SIRT2和SIRT3的IC₅₀值分别为 0.54，0.253，0.72 μM。SIRT1/2/3-IN-1 (compound 10) 可用于癌症研究。

生物活性

SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor ofSIRT1,SIRT2andSIRT3withIC₅₀s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research ofcancer^[1].

IC₅₀& Target

IC50: 0.54 μM (SIRT1), 0.253 μM (SIRT2), and 0.72 μM (SIRT3)^[1]

体外研究
(In Vitro)

SIRT1/2/3-IN-1 (compound 10) possesses cell growth inhibition to cancer cells with time- and concentration-dependently^[1].

Western Blot Analysis^[1]

Cell Line:	HCT116 human colon cancer cells
Concentration:	0, 0.5, 2, 10, 50, and 100 μM
Incubation Time:	8 h
Result:	Inhibited deacetylation of the K382-acetylated tumor suppresser protein p53.

Cell Proliferation Assay^[1]

Cell Line:	Human MCF-7 breast cancer cells and human SK-MEL-2 melanoma cells
Concentration:	0, 5, 12.5, 25, 50 or 100 μM
Incubation Time:	24 h, 48 h or 72 h
Result:	Concentration-dependently inhibited cell growth.

分子量

934.18

Formula

C₄₆H₆₃N₉O₈S₂

CAS 号

2413212-06-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.