您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > SIRT1/2/3-IN-1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SIRT1/2/3-IN-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SIRT1/2/3-IN-1图片
CAS NO:2413212-06-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
SIRT1/2/3-IN-1 (compound 10) 是一种高效的,选择性的和细胞渗性的 SIRT1/2/3 抑制剂,抑制SIRT1SIRT2SIRT3IC50值分别为 0.54,0.253,0.72 μM。SIRT1/2/3-IN-1 (compound 10) 可用于癌症研究。
生物活性

SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor ofSIRT1,SIRT2andSIRT3withIC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research ofcancer[1].

IC50& Target

IC50: 0.54 μM (SIRT1), 0.253 μM (SIRT2), and 0.72 μM (SIRT3)[1]

体外研究
(In Vitro)

SIRT1/2/3-IN-1 (compound 10) possesses cell growth inhibition to cancer cells with time- and concentration-dependently[1].

Western Blot Analysis[1]

Cell Line:HCT116 human colon cancer cells
Concentration:0, 0.5, 2, 10, 50, and 100 μM
Incubation Time:8 h
Result:Inhibited deacetylation of the K382-acetylated tumor suppresser protein p53.

Cell Proliferation Assay[1]

Cell Line:Human MCF-7 breast cancer cells and human SK-MEL-2 melanoma cells
Concentration:0, 5, 12.5, 25, 50 or 100 μM
Incubation Time:24 h, 48 h or 72 h
Result:Concentration-dependently inhibited cell growth.
分子量

934.18

Formula

C46H63N9O8S2

CAS 号

2413212-06-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.