Ruboxistaurin-d6 (LY333531-d6) hydrochloride is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selectivePKCbetainhibitor (K_i=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition ofPKCbeta I with anIC₅₀of 4.7 nM. Ruboxistaurin hydrochloride inhibitsPKCbeta II with anIC₅₀of 5.9 nM^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

511.04

C₂₈H₂₃D₆ClN₄O₃

1794767-04-6

鲁伯斯塔盐酸盐 d6 (盐酸盐)

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.