Hydrochlorothiazid-d2 (HCTZ-d2) is the deuterium labeled Hydrochlorothiazide. Hydrochlorothiazide (HCTZ), an orally active diuretic drug of the thiazide class, inhibits transformingTGF-β/Smadsignaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of thecalcium-activated potassium (KCA)channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect^[1][2][3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

299.75

Solid

C₇H₆D₂ClN₃O₄S₂

1219798-89-6

氢氯噻嗪 d2

Room temperature in continental US; may vary elsewhere.