| CAS NO: | 1429239-98-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 751.67 |
|---|---|
| Formula | C33H31Cl2F3N6O3S2 |
| CAS No. | 1429239-98-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 10 mM |
| Water: N/A | |
| Ethanol: N/A | |
| Solubility (In vivo) | 1-(2,4-Dichloro-phenyl)-4-[(pyrrolidine-1-sulfonylamino)-methyl]-5-[5-(4-trifluoromethyl-phenylethynyl)-thiophen-2-yl]-1H-pyrazole-3-carboxylic acid piperidin-1-ylamide |
| Synonyms | DBPR 211; DBPR211; DBPR-211; CB1-IN-1; CB1-IN1; CB1 IN 1; CB1IN 1; CB1IN-1 |
| SMILES Code | O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C#CC4=CC=C(C(F)(F)F)C=C4)S3)=C1CNS(=O)(N5CCCC5)=O)NN6CCCCC6 |
| In Vitro | In vitro activity: CB1-IN-1 is a novel peripherally restricted CB1R antagonist, with Ki of 0.3 nM and 21 nM for CB1R (EC50 = 3 nM) and CB2R, respectively. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | CB1-IN-1 has significant weight-loss efficacy in diet-induced obese mice. |
| Animal model | |
| Formulation & Dosage | |
| References |
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