CAS NO: | 2275774-60-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | BAY 2666605 is an orally activePDE3AandPDE3Binhibitor withIC50s of 87 nM and 50 nM, respectively. BAY 2666605 is aPDE3A-SLFN12complex inducer (WO2019025562A1; example 135)[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | BAY 2666605 (example 135) has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer[1]. | ||||||||||||||||
体内研究 (In Vivo) | BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 352.28 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H12F4N2O2 | ||||||||||||||||
CAS 号 | 2275774-60-0 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 250 mg/mL(709.66 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |