Thioquinapiperifil (KF31327 free base) 是有效的、选择性的、非竞争性的磷酸二酯酶(PDE-5)(IC50为 0.074 nM) 的抑制剂，可用于性成熟的研究。
| 生物活性 | Thioquinapiperifil (KF31327 free base), a potent, selective and non-competitivephosphodiesterase-5 (PDE-5,IC50of 0.074 nM) inhibitor, is used for sexual enhancement study[1][2]. |
| IC50& Target[2] | PDE5 0.074 nM (IC50) | PDE1 380 nM (IC50) | PDE2 670 nM (IC50) | PDE3 38 nM (IC50) | PDE4 800 nM (IC50) |
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体外研究
(In Vitro) | Thioquinapiperifil can be found in dietary supplements[1].
Thioquinapiperifil (KF31327 free base) (0.1-10 μM) concentration dependently inhibits platelet aggregation. In the absence of nitroglycerin, higher concentrations 1 and 10 μM of Thioquinapiperifil (KF31327 free base) are required to inhibit platelet aggregation[2].
Thioquinapiperifil (KF31327 free base) and shows significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of Thioquinapiperifil (KF31327)-treated cells is 0.95±0.17 pmol/108cells[2].
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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