Pseudocoptisine (Isocoptisine) acetate is a quaternary alkaloid with benzylisoquinoline skeleton, was isolated from Corydalis Tuber. Pseudocoptisine acetate inhibitsacetylcholinesterase (AChE)activity with anIC₅₀of 12.8 μM. Anti-inflammatory and anti-amnestic effects^[1][2].

Pseudocoptisine (0, 60, 90 μM; 1 hour) dose-dependently inhibited LPS-induced NO production in RAW264.7 cells^[2].
Pseudocoptisine (30-90 μM; 1 hour; RAW264.7 cells) significantly reduces the LPS-induced TNF-α and IL-6 production and their mRNA expressions^[1].
Pseudocoptisine acetate reduces levels of the pro-inflammatory mediators, such as, iNOS, COX-2, TNF-alpha, and IL-6 through the inhibition of NF-kappaB activation via the suppression of ERK and p38 phosphorylation in RAW 264.7 cells^[1].

The anti-amnesic activities of Pseudocoptisine in mice on the learning and memory impairments induced by scopolamine (1.0 mg/kg, i.p.) are examined. Pseudocoptisine (2.0 mg/kg, p.o.) significantly reverses cognitive impairments in mice by passive avoidance test^[1].

379.36

C₂₁H₁₇NO₆

30426-66-5

异黄连碱乙酸盐

• Alkaloids
• Isoquinoline Alkaloids

• Plants
• Rutaceae
• Phellodendron amurenseRupr.

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Please store the product under the recommended conditions in the Certificate of Analysis.