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Antimicrobial agent-8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antimicrobial agent-8图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Antimicrobial agent-8 (Compound 15) 是一种有效的抗菌剂,对革兰氏阴性和革兰氏阳性菌表现出强大的抗菌活性,MIC 范围为 2-8 μg/mL。Antimicrobial agent-8 对脂多糖引起的炎症表现出抗炎活性。
生物活性

Antimicrobial agent-8 (Compound 15) is a potentantimicrobial agent, and shows potent antimicrobial activity with anMICrange of 2-8 μg/mL against Gram-negative and Gram-positive bacteria. Antimicrobial agent-8 shows anti-inflammatory activity against lipopolysaccharide-induced inflammation.

体外研究
(In Vitro)

Antimicrobial agent-8 (2.8-56.4 μM; 24 h) inhibits Gram-negative bacteria and Gram-positive bacteria growth[1].
Antimicrobial agent-8 (5 and 20 μg/mL; 18 h) inhibits the production of nitric oxide (NO) and tumor necrosis factor-α (TNF-α) by lipopolysaccharide-stimulated in RAW 264.7 cells[1].
Antimicrobial agent-8 (1-32 μg/mL, 16 h; 8-128 μg/mL; 24 h) shows potent biofilm inhibitory (MBIC50=1 μg/mL) and eradicating activities (MBEC50=8 μg/mL) by MDRPA bacteria[1].
Antimicrobial agent-8 exhibits proteolytic resistance and salt/serum stability[1].
Antimicrobial agent-8 displays synergistic or additive effects when combined with selected clinically used antibiotics[1].

Cell Viability Assay[1]

Cell Line:E. coli[KCTC 1682],P. aeruginosa[KCTC 1637],S. epidermidis[KCTC 1917] andS. aureus[KCTC1621]
Concentration:2.8-56.4 μM
Incubation Time:24 hours
Result:Inhibited Gram-negative bacteria with MIC values of 5.4 μM forE. coli[KCTC 1682] andP. aeruginosa[KCTC 1637].
Inhibited Gram- positive bacteria with MIC values of 2.7 μM and 5.4 μM forS. epidermidis[KCTC 1917] andS. aureus[KCTC1621], respectively.

Cell Viability Assay[1]

Cell Line:RAW 264.7 macrophages
Concentration:5 and 20 μg/mL
Incubation Time:18 hours
Result:Observed LPS-stimulated production of NO with an inhibitory rate of 90.79% at 5 μg/mL.
Exhibited inhibitory effects on the LPS-stimulated production of TNF-α with an inhibitory rate of 95.4% at 20 μg/mL.
分子量

746.95

Formula

C39H54N16

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.