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ABAI-30
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ABAI-30图片
CAS NO:2757957-25-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ABAI-30 是一种有效且具有口服活性的抗炎剂。ABAI-30 有效抑制脂多糖 (LPS) 诱导的 RAW264.7 细胞中 NO 的产生。
生物活性

ABAI-30 is a potent and orally active anti-inflammatory agent. ABAI-30 effectively inhibits NO production in lipopolysaccharide (LPS) induced RAW264.7 cells[1].

体外研究
(In Vitro)

In RAW264.7 cells, ABAI-30 (10-40 μM) inhibits the TLR4-pp65 and NLRP3-caspase-1 signaling pathway, thus leading to the downregulation of IL6, IL-1β and TNFα at both transcriptional and translational levels[1].

体内研究
(In Vivo)

In a dextran sulfate sodium (DSS)-induced colitis mouse model, ABAI-30 (25 mg/kg; oral administration; for 5 days) demonstrates high in vivo anti-inflammatory efficacy without causing obvious toxicity[1].

分子量

347.33

Formula

C17H13N7O2

CAS 号

2757957-25-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.