CLEFMA 是一种具有抗肿瘤活性的姜黄素。CLEFMA 抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关。
| 生物活性 | CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2]. |
体外研究
(In Vitro) | CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity[1].
CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2].
CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells[2].
CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells[1].
CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].
Cell Proliferation Assay[1] | Cell Line: | PANC-1, MiaPaCa-2, PC-3 and H441 cells | | Concentration: | 1, 10, 25, 100 μM | | Incubation Time: | 24, 48, 72 h | | Result: | Inhibits cells proliferation in a dose-dependent manner. |
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体内研究
(In Vivo) | CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model[2].
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue[2].
| Animal Model: | Male athymic nu/nu mice (4 weeks old) are injected H441 cells[2] | | Dosage: | 0.2, 0.4 mg/kg | | Administration: | I.p. daily for 4 weeks | | Result: | Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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