PTD-p65-P1 Peptide is a potent, selective nuclear transcription factorNF-κBinhibitor and derives from the p65 subunit ofNF-κBamino acid residues 271-282, which selectively inhibitsNF-κBactivation induced by various inflammatory stimulation, down-regulate NF-κB-mediated gene expression and up-regulateapoptosis^[1][2].

NF-kappaB^[1]

PTD-p65-P1 Peptide (10-150 μM; 0-60 min; KBM-5 cells) inhibits TNF-induced NF-κB activation in a dose-dependent manner and suppresses TNF-induced NF-κB activation by 25% at 100 μM and completely at 150 μM^[1].
PTD-p65-P1 Peptide (150 μM; 0-60 min; KBM-5 cells) inhibits cytoplasmic p65 phosphorylation and nuclear translocation^[1].
PTD-p65-P1 Peptide (100 μM; 16 h; KBM-5 cells) potentiates the TNF-induced apoptosis from 4 to 45%^[1].
PTD-p65-P1 Peptide (150 μM; A 293 cells) inhibits NF-κB-dependent reporter gene expression induced by TNF^[1].
PTD-p65-P1 Peptide (150 μM; 12-24 h; SP-53 cells ) inhibits the cell proliferation^[2].

3829.50

C₁₆₈H₂₇₅N₅₇O₄₄S

DRQIKIWFQNRRMKWKKQLRRPSDRELSE

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Please store the product under the recommended conditions in the Certificate of Analysis.