NF110 is aP2X₃receptor antagonist (K_i= 36 nM) and inactive toward P2Y receptors stably expressed (IC₅₀s >10 M). NF110 blocks alphabeta-methylene-ATP-induced currents (IC₅₀= 527 nM) in rat dorsal root ganglia neurons^[1].

Ki: 36 nM (P2X3 Receptor)

NF110 shows an activity in the human tumour cell line panel, with IC₃₀of 362.3 μM^[2].
NF110 inhibits HMGA2-DNA interactions with an IC₅₀of 0.87 μM^[3].

NF110 shows potency at Endogenous P2X Receptors in Rat DRG Neurons, with a peak amplitude of 675 pA^[1].

1096.91

C₄₁H₂₈N₆Na₄O₁₇S₄

111150-22-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.