Chloropyramine

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Chloropyramine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

59-32-5

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

氯吡拉敏

产品介绍

Chloropyramine 是竞争性可逆 H1 受体拮抗剂。Chloropyramine 在乳腺癌中也具有抗肿瘤活性。Chloropyramine 可用于过敏性疾病的研究，如结膜炎和支气管哮喘。

生物活性

Chloropyramine is competitive reversibleH1 receptorantagonist. Chloropyramine also has anti-tumour activity in breastcancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma^[1]^[2].

IC₅₀& Target^[1]

H₁Receptor

体外研究
(In Vitro)

Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines^[1].

Western Blot Analysis^[1]

Cell Line:	Breast cancer cell lines
Concentration:	25 or 50 μM
Incubation Time:	24 h
Result:	Increased SASH1 expression in breast cancer cell lines.

Apoptosis Analysis^[1]

Cell Line:	T47D, MDA-MB-231 and BT-54 cells
Concentration:	50 μM
Incubation Time:	48 h
Result:	Induced apoptosis in breast cancer cell lines.

体内研究
(In Vivo)

Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats^[2].

Animal Model:	Rats^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal
Result:	Reduced histamine-induced hypothermia.

分子量

289.80

Formula

C₁₆H₂₀ClN₃

CAS 号

59-32-5

中文名称

氯吡拉敏

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.