| CAS NO: | 130465-39-3 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 130465-39-3 |
| 别名 | 1-(氨基甲基)-3,4-二氢-3-苯基-1H-2-苯并吡喃-5,6-二醇盐酸盐 |
| 化学名 | (1R,3S)-1-(aminomethyl)-3-phenylisochroman-5,6-diol hydrochloride |
| Canonical SMILES | OC(C1=C(C=C2)[C@H](CN)O[C@H](C3=CC=CC=C3)C1)=C2O.Cl |
| 分子式 | C16H17NO3.HCl |
| 分子量 | 307.78 |
| 溶解度 | <15.39mg/ml in Water |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | A 68930 hydrochloride is a potent and selective agonist of D1 dopamine receptor with EC50 values of 2.5 and 3920 nM for D1 and D2 receptors, respectively [1]. D1 dopamine receptor is a G-protein couple receptor for dopamine and stimulates adenylate cyclase and cyclic AMP-dependent protein kinases. D1 dopamine receptor plays an important role in behavioral responses and neuronal growth and development. A 68930 hydrochloride is a potent and selective D1 dopamine receptor agonist. In rats, A 68930 (0.9-15.0 μM) induced hypothermia in a dose-dependent way. Also, A 68930 (0.9-15.0 μM) inhibited locomotor activity in a dose-dependent way [2]. In adult rat, A 68930 (0.0625-4.0 mg/kg) induced grooming, vacuous chewing and sniffing, which were inhibited by SCH 23390, a D1-like receptor antagonist [3]. In chronic unpredictable (CUS) stress rat models, A68930 (0.25 mg/kg) significantly normalized the reduction of the number of tyrosine hydroxylase (TH) immunoreactive neurons in the striatum, ventral tegmental area, medial forebrain bundle and substansia nigra and glucocorticoid receptor (GR) in the cortex, hippocampus and striatum. Also, A68930 normalized the antioxidant enzyme activities, increased glutathione (GSH) and inhibited lipid peroxidation [4]. References: |
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