Gd-NMC-3 是一种近红外荧光/磁共振 (NIRF/MR) 双峰成像探针。Gd-NMC-3 在肿瘤成像中具有高分辨率和灵敏度，并且生物相容性好。
| 生物活性 | Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential[1]. |
体外研究
(In Vitro) | Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region[1].
Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites[1].
Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues[1].
Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors[1].
Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility[1].
Cell Cytotoxicity Assay[1] | Cell Line: | HepG2 and LM3: human hepatocarcinoma cell line; L02: human hepatocyte cell line | | Concentration: | 6.25-100 μM | | Incubation Time: | 48 hours | | Result: | Resulted more than 90% cell viability maintained after 48 h. |
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体内研究
(In Vivo) | Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors[1].
| Animal Model: | HepG2 subcutaneous xenograft mice[1] | | Dosage: | 20 mg/kg | | Administration: | Intravenous injection; 1.5 h later dissected tumors | | Result: | Accumulated in the tumor after injection and produced stronger fluorescence intensity in tumor tissues.
Remained fluorescence signal longer than 1.5 h, and provided high-resolution images of the tumor tissues with a SNR of 4.32. |
| Animal Model: | LM3 orthotopic mice[1] | | Dosage: | 20 mg/kg | | Administration: | Intravenous injection | | Result: | Decreased gradually the fluorescence intensity in LM3 orthotopic liver tumors after administration, whereas tumor-to-skin fluorescence ratios increased due to high accumulation and low clearance in tumor tissues. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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