H-L-Phe(4-NH-Poc)-OH (hydrochloride) is aclick chemistryreagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported^[1][2].

298.72

C₁₃H₁₅ClN₂O₄

2737202-66-1

Room temperature in continental US; may vary elsewhere.

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