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CAY10640
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAY10640图片
CAS NO:1208549-68-1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
CAY10640 (compound TCPU ) 是一种有效的口服活性 sEH(可溶性环氧化物水解酶)抑制剂,在人和鼠中的 IC50 分别为 0.4 和 5.3 nM。
Cas No.1208549-68-1
化学名N-[1-(cyclopropylcarbonyl)-4-piperidinyl]-N'-[4-(trifluoromethoxy)phenyl]-urea
Canonical SMILESO=C(NC1CCN(C(C2CC2)=O)CC1)NC3=CC=C(OC(F)(F)F)C=C3
分子式C17H20F3N3O3
分子量371.4
溶解度DMF: 5 mg/ml,DMSO: 5 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: 2 mg/ml,PBS (pH 7.2): Isoluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述 Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that inhibits recombinant human and mouse sEH with IC50 values both equal to 0.4 nM. CAY10640 demonstrates a 1,000-fold increase in potency compared to morphine in reducing hyperalgesia in an in vivo carrageenan-induced inflammatory pain model.