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Flopropione
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flopropione图片
CAS NO:2295-58-1
包装:50mg
市场价:473元

产品介绍
Flopropione 是一种 5-HT 受体拮抗剂,也是一种儿茶酚-邻甲基转移酶 (COMT) 抑制剂。
Cas No.2295-58-1
别名夫洛丙酮
化学名1-(2,4,6-trihydroxyphenyl)propan-1-one
Canonical SMILESCCC(=O)C1=C(C=C(C=C1O)O)O
分子式C9H10O4
分子量182.17
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Flopropione is a 5-HT receptor antagonist and also a catechol-o-methyltransferase (COMT) inhibitor[1][2]. Flopropione also as an antispasmodic agent[3].

The effect of Flopropione as an antispasmodic agent on the rate of passing a calculus from the urinary tract has been compared retrospectively with patients in whom passage was spontaneous. Flopropine has been shown, with statistical significance, to be superior to the control in cumulative passage rate after initiation of administration. Flopropine has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreatobiliary and urinary systems[3].

References:
[1]. Burns SM, et al. High-throughput luminescent reporter of insulin secretion for discovering regulators of pancreatic Beta-cell function. Cell Metab. 2015 Jan 6;21(1):126-37.
[2]. C Barlow, et al. Modulation of neurogenesis using d-cycloserine combinations. 2010-08-26. PAT - US2010216805.
[3]. Ohgaki K, et al. Facilitation of expulsion of ureteral stones by addition of α1-blockers to conservative therapy. Scand J Urol Nephrol. 2010 Dec;44(6):420-4.