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Homatropine Methylbromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Homatropine Methylbromide图片
CAS NO:80-49-9
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Homatropinemethylbromide (Homatropine methobromide) 是毒蕈碱型 AChR 拮抗剂，抑制 WKY-E 和 SHR-E 的内皮和平滑肌毒蕈碱受体，IC50 分别为 162.5 nM 和 170.3 nM。
Cas No.80-49-9
别名溴甲后马托品,Homatropine methobromide
化学名[(1R,5S)-8,8-dimethyl-8-azoniabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate;bromide
Canonical SMILESC[N+]1(C2CCC1CC(C2)OC(=O)C(C3=CC=CC=C3)O)C.[Br-]
分子式C17H24NO3.Br
分子量370.28
溶解度≥ 17.95mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Homatropine methylbromide (Homatropine methobromide) is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.

Homatropine methylbromide (Homatropine methobromide) (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine methylbromide (Homatropine methobromide) (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.

Pre-treatment with Homatropine methylbromide (Homatropine methobromide) (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning.

References:
[1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study.Clin Exp Hypertens. 1993 Mar;15(2):409-21.
[2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9.
[3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig.Eur J Pharmacol. 1982 May 7;80(1):11-7.