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Lipoxin A4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lipoxin A4图片
CAS NO:89663-86-5
包装与价格：
包装价格(元)
25 μg电议
50 μg电议
100 μg电议
250 μg电议

产品介绍
脂氧素 A4 (LXA4) 是一种内源性脂氧合酶衍生的类花生酸介质，具有强大的双重促分解和抗炎特性。
Cas No.89663-86-5
别名脂氧素 A4; LXA4
化学名5S,6R,15S-trihydroxy-7E,9E,11Z,13E-eicosatetraenoic acid
Canonical SMILESCCCCC[C@H](O)/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)CCCC(O)=O
分子式C20H32O5
分子量352.5
溶解度A solution in ethanol, can isomerize and degrade when put into freeze thaw conditions or in solvents such as DMSO, or DMF, 50 mg/ml in Ethanol, 1 mg/ml in PBS (pH 7.2)
储存条件Store at -80℃, protect form light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Lipoxin A4 (LXA4) is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of (±)15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 in inducing superoxide generation in human neutrophils at 0.1 μM.2 LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural killer cell inhibition, and monocyte migration and adhesion.[2],[3],[4] Analytical and biological comparisons of synthetic LXA4 with endogenously derived LXA4 have confirmed its identity as matching the natural product.[5]

Reference:
[1]. Serhan, C.N., Nicolaou, K.C., Webber, S.E., et al. Lipoxin A. Stereochemistry and biosynthesis. J. Biol. Chem. 261(35), 16340-16345 (1986).
[2]. Serhan, C.N., Hamberg, M., and Samuelsson, B. Lipoxins: Novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc. Natl. Acad. Sci. U.S.A. 81(17), 5335-5339 (1984).
[3]. Ramstedt, U., Serhan, C.N., Nicolaou, K.C., et al. Lipoxin A-induced inhibition of human natural killer cell cytotoxicity: Studies on stereospecificity of inhibition and mode of action. J. Immunol. 138(1), 266-270 (1987).
[4]. Maddox, J.F., and Serhan, C.N. Lipoxin A4 and B4 are potent stimuli for human monocyte migration and adhesion: Selective inactivation by dehydrogenation and reduction. J. Exp. Med. 183(1), 137-146 (1996).
[5]. Serhan, C. . (2007).