您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > 3-Methylcrotonyl Glycine
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
3-Methylcrotonyl Glycine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
3-Methylcrotonyl Glycine图片
CAS NO:33008-07-0
包装与价格：
包装价格(元)
10mg电议
50mg电议
100mg电议
250mg电议

产品介绍
3-甲基巴豆酰甘氨酸是一种酰基甘氨酸，一种在尿液中发现的正常氨基酸代谢物。
Cas No.33008-07-0
别名N-(3-甲基-1-氧代-2-丁烯基)氨基乙酸
化学名N-(3-methyl-1-oxo-2-buten-1-yl)-glycine
Canonical SMILESOC(CNC(/C=C(C)/C)=O)=O
分子式C7H11NO3
分子量157.2
溶解度50mg/mL in ethanol, 20mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

3-Methylcrotonyl glycine (3-MCG) is a metabolite found in the urine of patients with 3-methylcrotonyl glycinuria, a metabolic disorder characterized by a deficiency in 3-methylcrotonyl-CoA carboxylase, that has diverse biological activities.[1] [2] It inhibits CO2 production and mitochondrial complex II-III and creatine kinase activity in rat cerebral cortex preparations in a concentration-dependent manner.[2] It also inhibits the Na+/K+-ATPase in purified synaptic membranes from rat cerebrum, indicating a potential role for this metabolite in the development of CNS damage associated with 3-methycrotonyl glycinuria.

Reference:
[1]. Bartlett, K., Ng, H., and Leonard, J.V. A combined defect of three mitochondrial carboxylases presenting as biotin-responsive 3-methylcrotonyl glycinuria and 3-hydroxyisovaleric aciduria. Clin. Chim. Acta. 100(2), 183-186 (1980).
[2]. Moura, A.P., Ribeiro, C.A., Zanatta, A., et al. 3-Methylcrotonylglycine disrupts mitochondrial energy homeostasis and inhibits synaptic Na+,K+-ATPase activity in brain of young rats. Cell. Mol. Neurobiol. 32(2), 297-307 (2012).