您好，欢迎来到试剂仪器网！ [登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > Tetrahydroberberine,THB
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Tetrahydroberberine,THB
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tetrahydroberberine,THB图片
CAS NO:522-97-4
包装:20mg
市场价:1449元

产品介绍
Tetrahydroberberine,THB是一种从延胡索块茎中分离得到的异喹啉生物碱；对多巴胺 D(2) (pK(i) = 6.08) 和 5-HT(1A) (pK(i) = 5.38) 受体具有微摩尔亲和力，但对其他相关血清素受体 (5-HT(1B) 具有中等或无亲和力、5-HT(1D)、5-HT(3) 和 5-HT(4)；pK(i)< 5.00)。
Cas No.522-97-4
别名四氢小檗碱; Canadine
Canonical SMILESCOC1=C(C2=C(CC3C4=CC5=C(C=C4CCN3C2)OCO5)C=C1)OC
分子式C20H21O4N
分子量339.39
溶解度≥ 16.95mg/mL in DMSO with ultrasonic
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i)< 5.00).

References:
[1]. Lee TH, et al. Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function. J Pharmacol Exp Ther. 2011 Sep;338(3):917-24.
[2]. Niwa M, et al. Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate. Pharmacology. 1991;43(6):329-36.