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ZXH-1-161
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ZXH-1-161图片
CAS NO:2407654-51-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
ZXH-1-161 是一种有效的 cereblon (CRBN) 调节剂,在野生型 MM1.S 细胞中的 IC50 为 39 μM。ZXH-1-161 对 GSPT1 具有选择性降解活性。ZXH-1-161 可用于多发性骨髓瘤的研究。
Cas No.2407654-51-5
分子式C26H24N6O3
分子量468.51
溶解度DMSO : 250 mg/mL (533.61 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma[1].

[1]. Powell CE, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020 Oct 16;15(10):2722-2730.