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Raclopride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Raclopride图片
CAS NO:84225-95-6
包装与价格:
包装价格(元)
10mM 1 mL in DMSO电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Raclopride 是一种多巴胺 D2/D3 受体拮抗剂,具有潜在的抗精神病作用。
Cas No.84225-95-6
别名雷氯必利
化学名(S)-3,5-dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide
Canonical SMILESClC1=C(C(C(NC[C@H]2N(CC)CCC2)=O)=C(C(Cl)=C1)O)OC
分子式C15H20Cl2N2O3
分子量347.24
溶解度DMF: 15 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 15 mg/ml,Ethanol: 1 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively[1].

References:
[1]. Seeman P, et al. Dopamine receptor pharmacology. Trends Pharmacol Sci. 1994 Jul;15(7):264-70.