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Ibudilast(KC404,AV411,MN166)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ibudilast(KC404,AV411,MN166)图片
CAS NO:50847-11-5
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 230.31
Formula C14H18N2O
CAS No. 50847-11-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 46 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 46 mg/mL (199.7 mM)
Solubility (In vivo)~2.7 mg/mL in 10% DMSO : 90% (20% SBE-β-CD in saline)
~2.7 mg/mL in 10% DMSO : 40% PEG300 : 5% Tween-80 : 45% saline
~2.7 mg/mL in 10% DMSO : 90% corn oil
Synonyms

Ibudilast; AV-411, KC-404; KC 404; MN-166, AV 411, AV411, KC404; MN166, MN 166

Chemical Name: 2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one

Exact Mass: 230.1419

SMILES CodeCC(C)C(C1=C2C=CC=CN2N=C1C(C)C)=O
实验参考方法
In Vitro

In vitro activity: Ibudilast inhibits pro-inflammatory cytokines (IL-6, IL-1β, TNF-α), toll-like receptor 4 blockade (TLR-4); suppresses a macrophage migration inhibitory factor (MIF), upregulates the anti-inflammatory cytokine (IL-10) and promotes neurotrophic factors (GDNF, NGF, NT-4).

In VivoIbudilast is able to cross the blood-brain barrier and has a good tolerance. It inhibits platelet aggregation, improves cerebral blood flow and attenuates allergic reactions in clinical applications. In an animal model of encephalomyelitis, Ibudilast significantly attenuates inflammatory cell infiltration in the lumbar spinal cord. After oral administration, it is well absorbed and metabolized in the liver mainly to diOH-ibudilast, which has similar or even stronger pharmacological effects
Animal modelCarotid artery thrombosis model
Formulation & DosageDissolved in saline; 0.3 and 1.0 mg/kg; i.v.
ReferencesCardiovasc Drug Rev. 2001 Fall;19(3):215-25.