| CAS NO: | 293762-45-5 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Cas No. | 293762-45-5 |
| 化学名 | 2'-(4-aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-6-amine |
| Canonical SMILES | NC1=CC=C2N=C(C3=CC=C4N=C(C(C=C5)=CC=C5N)NC4=C3)NC2=C1 |
| 分子式 | C20H16N6 |
| 分子量 | 340.39 |
| 溶解度 | 15 mg/ml in DMF, 10 mg/ml in DMSO, 2 mg/ml in Ethanol |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ro 90-7501 is a bi-benzimidazole compound that was first found to retard the formation of mature amyloid β42 fibrils in a cell-based assay.[1] Instead, extended polymeric sheets and fibrillary intermediates of amyloid β42 accumulated in response to Ro 90-7501 treatment, resulting in reduced cytotoxicity (EC50 = 2 μM).1 More recently, Ro 90-7501 was shown to modulate signaling in cells stimulated with polyinosinic-polycytidylic acid (poly(I:C); a toll-like receptor 3 (TLR3), and RIG-1-like receptor agonist.[2] Ro 90-7501 (10 μM) enhanced poly(I:C)-induced IFN-β expression, decreased NF-κB activation, and amplified the suppression of vesiculastomatitis virus replication by poly(I:C) in HEK293 cells expressing TLR3.[2] Reference |
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