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CU-CPT-9b(TLR8-specific antagonist 1)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CU-CPT-9b(TLR8-specific antagonist 1)图片
CAS NO:2162962-69-6
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
CU-CPT-9b (TLR8-specific contrast 1) 是一种特异性 TLR8 拮抗剂，IC50 为 0.7 nM。
Cas No.2162962-69-6
Canonical SMILESOC1=C(C)C=C(C=C1)C2=CC=NC3=CC(O)=CC=C32
分子式C16H13NO2
分子量251.28
溶解度DMSO : 100 mg/mL (397.96 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM.

CU-CPT-9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT-9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT-9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT-9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT-9b as compared to TLR8/CU-CPT8m[1].

[1]. Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14(1):58-64.