IFN alpha-IFNAR-IN-1(IFN-alpha and IFNAR interaction inhibitor)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

844882-93-5

包装与价格：

产品介绍

IFN α-IFNAR-IN-1（IFN-α 和 IFNAR 相互作用抑制剂）是一种非肽类、低分子量的 IFN-α 相互作用抑制剂；和 IFNAR；抑制 MVA 诱导的 IFN-α； BM-pDCs 的反应 (IC50=2-8 uM)。

Cas No.	844882-93-5
Canonical SMILES	CNCC1=CC=CC=C1SC2=C(C=CC=C3)C3=CC=C2
分子式	C₁₈H₁₇NS
分子量	279.4
溶解度	Soluble in DMSO
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).IC50 value:Target: IFN alpha-IFNAR interaction inhibitorIFN alpha-IFNAR-IN-1 specifically inhibits MVA-induced IFN-α responses by BM-pDCs. IFN alpha-IFNAR-IN-1 inhibited the IFN-α responses that were elicited after treatment with CpG2216, stimulation with poly(I:C), and infection with VSV-M2, whereas the total IL-12 production was notably less affected under those conditions. IFN alpha-IFNAR-IN-1 exerts immunosuppressive activity by the direct interaction with IFN-α [1]. [1]. Geppert T, et al. Immunosuppressive small molecule discovered by structure-based virtual screening for inhibitors of protein-protein interactions. Angew Chem Int Ed Engl. 2012 Jan 2;51(1):258-61.