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Escin IIa
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Escin IIa图片
CAS NO:158732-55-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Escin IIa 是从欧洲七叶树中分离出来的,对动物急性炎症有积极作用。Escin IIa 对乙醇诱导的胃粘膜损伤有明显的保护作用。
生物活性

Escin IIa, isolated from horse chestnut, the seeds ofAesculus hippocastanumL., has positive effects on acute inflammation inanimals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats[1][2].

体内研究
(In Vivo)

Escins Ia, Ib, IIa, and IIb (50-200 mg/kg) inhibits the increase of vascular permeability induced by both acetic acid in mice and histamine in rats. Escins Ib, IIa, and IIb (50-200 mg/kg) also inhibit that induced by serotonin in rats, but escin Ia didn't. Escins Ia, Ib, IIa, and IIb (200 mg/kg) inhibit the hind paw edema induced by carrageenin at the first phase in rats. Escin Ia (200 mg/kg) and escins Ib, IIa, and IIb (50-200 mg/kg) inhibit the scratching behavior induced by compound 48/80 in mice, but escin Ia was weakest[1].
Escin IIa (10-50 mg/kg;p.o.;) potently inhibits ethanol-induced gastric mucosal lesions[2].

Animal Model:Male Sprague–Dawley rats (Ethanol-induced gastric mucosal lesions in rats)[1]
Dosage:10-50 mg/kg
Administration:p.o.
Result:Showed a potent protective effect against ethanol-induced gastric lesions in rats.
分子量

1101.23

Formula

C54H84O23

CAS 号

158732-55-9

结构分类
  • Terpenoids
  • Triterpenes
来源
  • Plants
  • Hippocastanaceae
  • Aesculus hippocastanum
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.