Yatein

立即咨询

Yatein

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

40456-50-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品名称

亚太因

产品介绍

Yatein 是从A. chilensis中提取的木质素，具有抗增殖活性。Yatein 能通过中断立早基因的表达，抑制单纯疱疹病毒 1 型(HSV-1)的复制。

生物活性

Yatein is a lignan isolated fromA. chilensis, with antiproliferative activity^[1]. Yatein suppressesherpes simplex virus type 1 (HSV-1 )replication by interruption the immediate-early gene expression^[2].

IC₅₀& Target

HSV-1^[2]

体外研究
(In Vitro)

Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells^[3].
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells^[3].
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization^[3].

Cell Cycle Analysis^[3]

Cell Line:	A549 cells, CL1-5 cells
Concentration:	1.25 μM , 2.5 μM , 5 μM
Incubation Time:	24 hours
Result:	Induced cell-cycle arrest at G2/M phase in both cell lines.

Western Blot Analysis^[3]

Cell Line:	A549 cells, CL1-5 cells
Concentration:	5 μM
Incubation Time:	6 hours, 12 hours
Result:	Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.

体内研究
(In Vivo)

Yatein (20 mg/kg; i.p.; five times per week; for 42 days) exhibits in vivo antitumor effects in a human lung adenocarcinoma xenograft mouse model^[3].

Animal Model:	Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft^[3]
Dosage:	20 mg/kg
Administration:	Intraperitoneal injection, five times per week, for 42 days
Result:	Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.

分子量

400.42

Formula

C₂₂H₂₄O₇

CAS 号

40456-50-6

中文名称

亚太因

结构分类

Phenylpropanoids
Lignans

来源

Plants
Cupressaceae
Chamaecyparis obtusa

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.