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Peramivir Trihydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Peramivir Trihydrate图片
CAS NO:1041434-82-5
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) 是一种高效、选择性和口服活性的流感病毒神经氨酸酶 (NA) 抑制剂，对九种 NA 亚型的 IC50 值为 0.9 至 4.3 nM。
Cas No.1041434-82-5
别名帕拉米韦三水合物; RWJ 270201 trihydrate; BCX 1812 trihydrate
化学名(1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid;trihydrate
Canonical SMILESCCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C.O.O.O
分子式C15H34N4O7
分子量382.45
溶解度≥ 19.1mg/mL in Water with gentle warming
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent, selective and orally active influenza virus neuraminidase (NA) inhibitor, with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes[1][2].

References:
[1]. Babu YS, et al. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. J Med Chem. 2000 Sep 21;43(19):3482-6.
[2]. Young D, et al. RWJ-270201 (BCX-1812): a novel neuraminidase inhibitor for influenza. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1905-13.