您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Hecogenin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Hecogenin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hecogenin图片
CAS NO:467-55-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
20mg电议
50mg电议
100mg电议
200mg电议

产品介绍
Hecogenin 是从剑麻 (Agave sisalana) 分离的类固醇皂苷,是人 UDP-葡萄糖醛酸糖基转移酶的选择性抑制剂。Hecogenin 具有广泛的药理活性,包括抗炎,抗真菌和胃保护作用。
生物活性

Hecogenin is a steroid saponin isolated fromAgave sisalanaand is a selective inhibitor ofhuman UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].

IC50& Target

Human UDP-glucuronosyltransferases[1]

体内研究
(In Vivo)

Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1].

Animal Model:Male Swiss mice (20-30 g) with ethanol[1]
Dosage:3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg
Administration:Oral administration; for 15 hours
Result:Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
分子量

430.62

性状

Solid

Formula

C27H42O4

CAS 号

467-55-0

结构分类
  • Steroids
来源
  • Plants
  • Agavaceae
  • Agave sisalanaPerr. ex Engelm.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMF : 16.67 mg/mL(38.71 mM;ultrasonic and warming and heat to 60℃)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)

H2O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.3222 mL11.6112 mL23.2223 mL
5 mM0.4644 mL2.3222 mL4.6445 mL
10 mM0.2322 mL1.1611 mL2.3222 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。