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15-Acetyldeoxy Nivalenol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
15-Acetyldeoxy Nivalenol图片
CAS NO:88337-96-6
包装:1mg
市场价:945元

产品介绍
15-Acetyldeoxy Nivalenol 是一种在谷物中发现的剧毒单端孢菌素，是脱氧雪腐镰刀菌烯醇的代谢物，对 HepG2 细胞具有毒性。
Cas No.88337-96-6
别名15-O-乙酰脱氧瓜萎镰菌醇
Canonical SMILESCC1=C[C@]2([H])[C@]([C@](C[C@H]3O)(C)C4(OC4)[C@]3([H])O2)(COC(C)=O)[C@H](O)C1=O
分子式C17H22O7
分子量338.4
溶解度Chloroform: soluble,Ethanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

15-Acetyldeoxy nivalenol is a trichothecene mycotoxin produced by certain species of the fungus Fusarium, particularly those found on cereal crops. It is an acetylated derivative of 4-deoxy nivalenol that can be converted to DON in the body. 15-Acetyldeoxy nivalenol induces vomiting and anorexia in livestock and experimental animals and its toxicity compared with DON is dependent upon the route of administration. It also changes brain bioamine neurotransmitter levels in pigs and chickens.

References:
[1].Ajandouz, E.H., Berdah, S., Moutardier, V., et al. Hydrolytic fate of 3/15-acetyldeoxynivalenol in humans: Specific deacetylation by the small intestine and liver revealed using in vitro and ex vivo approaches Toxins (Basel) 8(8), E232 (2016).
[2]. Pestka, J.J., Lin, W.-S., and Miller, E.R. Emetic activity of the trichothecene 15-acetyldeoxynivalenol in swine Food Chem. Toxicol. 25(11), 855-888 (1987).
[3].Payros, D., Alazzane-Kpembi, I., Pierron, A., et al. Toxicology of deoxynivalenol and its acetylated and modified forms Arch. Toxicol. 90(12), 2931-2957 (2016).
[4].Bonnet, M.S., Roux, J., Mounien, L., et al. Advances in deoxynivalenol toxicity mechanisms: The brain as a target Toxins (Basel) 4(11), 1120-1138 (2012).