Myristoleic acid 是Serenoa repens提取物中的一种细胞毒性成分，可诱导人前列腺细胞的凋亡和坏死。
| 生物活性 | Myristoleic acid, a cytotoxic component in the extract fromSerenoa repens, inducesapoptosisand necrosis in human prostatic LNCaP cells[1]. |
| IC50& Target | Human Endogenous Metabolite |
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体外研究
(In Vitro) | Myristoleic acid induces both apoptosis (100 μg/mL, 89.5%) and necrosis (100 μg/mL, 81.8%) in LNCaP cells[1].
Myristoleic acid inhibited RANKL-induced osteoclast formation in vitro, especially, at later stages of differentiation[2].
Cell Proliferation Assay[1] | Cell Line: | Human prostatic carcinoma LNCaP cells. | | Concentration: | 0, 50, 100, 150, 200, 250 μg/mL. | | Incubation Time: | 24 h. | | Result: | When LNCaP cells were treated with 130 μg/mL extract or 100 μg/mL myristoleic acid for 24 hr, the proportion of apoptotic cells was 16.5 and 8.8%, and that of necrotic one was 46.8 and 81.8%, respectively. |
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体内研究
(In Vivo) | Myristoleic acid (2 mg/kg, IP every 24 h for 4 days) prevents RANKL-induced bone loss and osteoclast formation in mice[2].
| Animal Model: | C57BL/6 mice at 5 weeks[2].
| | Dosage: | 0.2, 2 mg/kg | | Administration: | IP every 24 h for 4 days. | | Result: | Co-administration of myristoleic acid suppressed generation of TRAP-positive osteoclasts induced by sRANKL and attenuated the increases in osteoclastic indices of Oc.S/BS, N.Oc/B. Pm and ES/BS in a dose-dependent manner. |
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| Formula | |
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| 结构分类 | - Ketones, Aldehydes, Acids
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| 来源 | - Plants
- Palmae
- Serenoa repens
enterococci |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Pure form | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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