| CAS NO: | 158932-33-3 |
| 包装 | 价格(元) |
| 10mM (in 1mL Water) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 20mg | 电议 |
| Cas No. | 158932-33-3 |
| 别名 | (R,R)-亚麻木酚素; (R,R)-SDG; (R,R)-LGM2605 |
| Canonical SMILES | COC1=C(O)C=CC(C[C@@H](CO[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)CO)[C@@](CO[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)([H])CC4=CC(OC)=C(O)C=C4)=C1 |
| 分子式 | C32H46O16 |
| 分子量 | 686.7 |
| 溶解度 | Water : ≥ 100 mg/mL (145.62 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | Secoisolariciresinol diglucoside is a plant lignan isolated from flaxseed, an antagonist of platelet activating factor-receptor, and used as an antioxidant. Secoisolariciresinol diglucoside (SDG) inhibition of radiation induces DNA damage in irradiated lung cells. SDG (50 μM) significantly inhibits comet tail length in all cell types. Pre-treatment of SDG equally protects all three types of lung cells from radiation-induced DNA strand breaks. SDG (10-50 µM) alone does not elicit any adverse effect on the colony forming ability of all the three cell types as compared to their respective untreated control cells (100%)[2]. Secoisolariciresinol diglucoside (SDG, 15 mg/kg, p.o.) reduces hypercholesterolemic atherosclerosis of rabbits and this effect is releated to a decrease in serum cholesterol, LDL-C, and lipid peroxidation product and an increase in HDL-C and antioxidant reserve. SDG reduces total cholesterol (TC) and LDL-C by 33% and 35%, respectively, at week 8 but increases HDL-C significantly, by > 140%, as early as week 4. It also decreases TC/LDL-C and LDL-C/HDL-C ratios by -64%. There is an increase in aortic malondialdehyde and chemiluminescence in group 3, and they are lower in group 4 than in group 3. SDG reduces hypercholesterolemic atherosclerosis by 73%[1]. [1]. Prasad K. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation. 1999 Mar 16;99(10):1355-62. [2]. Velalopoulou A, et al. The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage. Int J Mol Sci. 2015 Dec 22;17(1). |
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