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TCID
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TCID图片
CAS NO:30675-13-9
规格:≥98%
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)283.92
FormulaC9H2Cl4O2
CAS No.30675-13-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 23 mg/mL (81.0 mM)
Water:<1 mg/mL
Ethanol: <1 mg/mL
SMILESO=C(CC1=O)C2=C1C(Cl)=C(Cl)C(Cl)=C2Cl
Synonyms4,5,6,7-tetrachloro-1H-indene-1,3(2H)-dione
实验参考方法
In Vitro

In vitro activity: TCID is selective for UCH-L3 over UCH-L1 by over 100-fold. NU6027 (10 μM) does not promote YFP-GLT-1 accumulation in intracellular vesicles in transfected MDCK cells, while LDN-57444 (10 μM) promotes YFP-GLT-1 accumulation. NU6027 (10 μM) does not produce long-term lysosomal degradation of GLT-1, while LDN-57444 (10 μM) has such effect. TCID (10 μM) diminishes GlyT2 ubiquitination in brainstem and spinal cord primary neurons, which is more pronounced when UCHL1 is inhibited and when cells are exposed to these inhibitors for longer periods.


Cell Assay: In transfected MDCK cells, TCID (10 μm for 30 mins) was not able to affect the UCH-L1 inhibitor promoted accumulation of YFP-GLT-1 in intracellular vesicles.

In Vivo
Animal model
Formulation & Dosage
References

Chem Biol. 2003 Sep;10(9):837-46; Glia. 2012 Sep;60(9):1356-65.