Vasicinone 是从鸭嘴花中分离得到的喹唑啉类生物碱。Vasicinone 是一种潜在的研究帕金森病和其他氧化应激相关神经退行性疾病的化合物。
| 生物活性 | Vasicinone is a quinazoline alkaloid isolated from theAdhatoda vasica. Vasicinone is a potential agent for Parkinson's disease and possibly other oxidative stress-related neurodegenerative disorders[1]. |
体外研究
(In Vitro) | Vasicinone (1~30 μM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability[1].
Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death[1].
Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins[1].
Cell Viability Assay[1] | Cell Line: | SH-SY5Y cells | | Concentration: | 1~30 μM | | Incubation Time: | 24 hours | | Result: | Significantly reversed the paraquat-induced reduction in cell viability. |
Western Blot Analysis[1] | Cell Line: | SH-SY5Y cells | | Concentration: | 10 and 15 μM | | Incubation Time: | 24 hours | | Result: | Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway. |
Apoptosis Analysis[1] | Cell Line: | SH-SY5Y cells | | Concentration: | 10 and 15 μM | | Incubation Time: | 24 hours | | Result: | Dose-dependently reduced the percentage of apoptotic cells. |
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| 结构分类 | - Alkaloids
- Pyrrole Alkaloids
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| 来源 | - Plants
- Acanthaceae
- Adhatoda vasicaNees
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| 溶解性数据 | In Vitro: DMSO : 50 mg/mL(247.27 mM;Need ultrasonic) 配制储备液 | 1 mM | 4.9454 mL | 24.7268 mL | 49.4535 mL | | 5 mM | 0.9891 mL | 4.9454 mL | 9.8907 mL | | 10 mM | 0.4945 mL | 2.4727 mL | 4.9454 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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