| CAS NO: | 84484-78-6 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 84484-78-6 |
| 别名 | 1-[1-(4-氯苯基)环丁基]-3-甲基丁胺盐酸盐 |
| 化学名 | (R)-1-(1-(4-chlorophenyl)cyclobutyl)-3-methylbutan-1-amine hydrochloride |
| Canonical SMILES | ClC1=CC=C(C=C1)C2([C@@H](CC(C)C)N)CCC2.Cl |
| 分子式 | C15H22NCl.HCl |
| 分子量 | 288.26 |
| 溶解度 | <28.83mg/ml in DMSO;<14.41mg/ml in Water |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 0.066 μM for noradrenaline uptake; 5.1 μM for 5-HT uptake; 0.31 μM for dopamine uptake Sibutramine HCl (BTS 54-524) is an inhibitor of the reuptake of monoamines with a pharmacological profile in rodents indicative of non-tricyclic putative antidepressant activity. BTS 54-505 is the primary amine metabolite of sibutramine. In vitro: Simultaneous application of BTS 54-505 with 5-HT resulted in a prolongation of the recovery time from the 5-HT-mediated suppression of discharge activity. BTS 54-505 also prolonged the recovery time from a NA-mediated potentiation of firing. These effects on recovery time are attributed to the inhibition of uptake of both 5-HT and NA by BTS 54-505. The amplitude of the response to 5-HT or NA was unaffected by co-ejection of BTS 54-505 [1]. In vivo: The secondary (BTS 54-354) and primary (BTS 54-505) amine metabolites of sibutramine HCl exhibit similar in vivo pharmacological activity to the parent compound. Thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2]. Clinical trial: Up to now, BTS 54-505 is still in the preclinical development stage. Reference: |
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