| CAS NO: | 1347744-96-0 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1347744-96-0 |
| 化学名 | (Z)-2-(4-(pyridin-2-yl)piperidin-1-yl)-N-(m-tolyl)acetimidic acid dihydrochloride |
| Canonical SMILES | CC1=CC(/N=C(O)/CN2CCC(C3=CC=CC=N3)CC2)=CC=C1.Cl.Cl |
| 分子式 | C19H23N3O.2HCl |
| 分子量 | 382.33 |
| 溶解度 | <38.23mg/ml in Water;<19.12mg/ml in DMSO |
| 储存条件 | Desiccate at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | A 412997 dihydrochloride is a selective agonist of dopamine D4 receptor with Ki values of 7.9 and 12.1 nM for human and rat D4 receptors, respectively [1]. Dopamine D4 receptor is a G protein-coupled receptor and is activated by dopamine. It plays an important role in cognition, Parkinsons disease, addictive behaviors and so on. A 412997 dihydrochloride is a selective dopamine D4 receptor agonist. In calcium flux functional assays, A-412997 activated the rat dopamine D4 receptor with EC50 value and intrinsic activity of 28.4 nM and 0.83, respectively [1]. In Spontaneous Hypertensive Rat pups (SHR pups), A 412997 significantly increased acquisition in the 5-trial repeated acquisition model. In the short-term social memory, A 412997 significantly shortened the second investigation time. In Wistar rats and Dawley rats, A 412997 (3 μM/kg, 10 μM/kg) increased locomotor activity [2]. In rats, A 412997 reduced non-rapid eye movement (NREM) sleep duration and increased waking duration. Also, A 412997 reduced rapid eye movement (REM) sleep duration and delayed the onset of REM sleep [3]. References: |
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