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Methoxy-X04
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Methoxy-X04图片
CAS NO:863918-78-9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Methoxy-X04 是一种荧光染料,可穿过血脑屏障并选择性地与致密核心淀粉样蛋白 Aβ 斑块中的 β 折叠片结合。
Cas No.863918-78-9
化学名4,4'-((1E,1'E)-(2-methoxy-1,4-phenylene)bis(ethene-2,1-diyl))diphenol
Canonical SMILESCOC1=C(C=CC(/C([H])=C([H])/C2=CC=C(O)C=C2)=C1)/C([H])=C([H])/C3=CC=C(O)C=C3
分子式C23H20O3
分子量344.4
溶解度5 mg/ml in ethanol; 30 mg/ml in DMSO and DMF
储存条件Store at -20℃,protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-β (Aβ) to detect and quantify plaques, tangles, and cerebrovascular amyloid.1 It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar β-sheet deposits and is used to image Aβ plaques in the brains of living APP/PS1 mice, a transgenic model of familial Alzheimer's disease.[1],[2] For in vivo imaging, APP/PS1 mice were injected with methoxy-X04 at a dose of 10 mg/kg, i.p., 24 hours prior to two-photon imaging.2 Methoxy-X04 displays an excitation peak at 750 nm with emission between 460 and 500 nm.[2]

Reference:
[1]. Klunk, W.E., Backsai, B.J., Mathis, C.A., et al. Imaging Aβ plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J. Neuropathol. Exp. Neurol. 61(9), 797-805 (2002).
[2]. Burgold, S., Bittner, T., Dorostkar, M.M., et al. In vivo multiphoton imaging reveals gradual growth of newborn amyloid plaques over weeks. Acta. Neuropathol. 121(3), 327-335 (2011).