Daucosterol is a natural sterolin. IC50 value: Target: In vitro: In the study of the effects of daucosterol on the survival of cultured cortical neurons after neurons were subjected to oxygen and glucose deprivation and simulated reperfusion (OGD/R)(2), the results showed that post-treatment of daucosterol significantly reduced neuronal loss, as well as apoptotic rate and caspase-3 activity, displaying the neuroprotective activity. We also found that daucosterol increased the expression level of IGF1 protein, diminished the down-regulation of p-AKT(3) and p-GSK-3β(4), thus activating the AKT(5) signal pathway [1]. Cell counting kit-8 (CCK-8) assay showed that daucosterol significantly increased the quantity of viable cells and the effectiveness of daucosterol was similar to that of basicfibroblast growth factor(bFGF) and epidermal growth factor (EGF) [2]. Daucosterol inhibits the proliferation of human breastcancercell line MCF-7 and gastriccancercell lines MGC803, BGC823 and AGS in a dose-dependent manner. Furthermore, daucosterol inhibits murine hepatoma H22 cell growth in ICR mice. Daucosterol treatment induces intracellular ROS generation andautophagy, but not apoptotic cell death. Treatment with ROS scavenger GSH (reduced glutathione), NAC (N-acetyl-l-cysteine) orautophagy inhibitor3-Methyladenine (3-MA) counteracted daucosterol-inducedautophagyand growth inhibition in BGC823 and MCF-7cancercells [3]. In vivo:

576.85

Solid

C₃₅H₆₀O₆

474-58-8

胡萝卜苷；西托糖苷；胡萝卜甙

• Steroids

• Plants
• Araliaceae
• Acanthopanax senticosus(Rupr. et Maxim.) Harms

Room temperature in continental US; may vary elsewhere.

DMSO : 3.33 mg/mL(5.77 mM;Need ultrasonic)

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