| CAS NO: | 65666-07-1 |
| 包装 | 价格(元) |
| 250mg | 电议 |
| 500mg | 电议 |
| 1 g | 电议 |
| 5 g | 电议 |
| 生物活性 | Silymarin is an extract of the milk thistle (Silybum marianum). Silymarin is an effectiveSARS-CoV-2 main protease (Mpro)inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well asinsulinresistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC). Silymarin has the potential for COVID-19 research[1][2][4]. | |||||||||
| 体外研究 (In Vitro) | Silymarin (0-120 μg/ml; 24 hours) inhibits AGS cell viability, the viability of AGS cells is 77.9% in the presence of 20 μg/ml silymarin, 71.5% at 40 μg/ml, 59.8% at 60 μg/ml, 44.5% at 80 μg/ml, 35.3% at 100 μg/ml and 33.9% at 120 μg/ml[1].Silymarin (40-80 μg/ml; 24 hours) inhibits the migration of the AGS cells in a concentration-dependent manner. It inhibit migration of AGS cells 59.4% at 40 μg/ml and 21.7% at 80 μg/ml,respectively[1]. Cell Viability Assay[2]
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| 体内研究 (In Vivo) | Silymarin (oral gavage; 10, 20, 50, 100, and 200 mg/kg) decreases the immobility time in a dose-dependent manner in forced swimming test (FST). It also lowers the immobility measure dose-dependently in tail suspension test (TST). Additionally, 50% of maximum response (ED50) of Silymarin is around 10 mg/kg. The dose 100 mg/kg proved the most effective dose in both the tests[3]. | |||||||||
| Clinical Trial | ||||||||||
| 性状 | Solid | |||||||||
| CAS 号 | 65666-07-1 | |||||||||
| 中文名称 | 水飞蓟素 | |||||||||
| 结构分类 |
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| 来源 |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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| 溶解性数据 | In Vitro: DMSO : 100 mg/mL(Need ultrasonic) In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂： ——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百
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