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VU 0361737
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
VU 0361737图片
CAS NO:1161205-04-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)262.69
FormulaC13H11ClN2O2
CAS No.1161205-04-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 53 mg/mL (201.8 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILES O=C(C1=NC=CC=C1)NC2=CC=C(Cl)C(OC)=C2
Synonyms VU 0361737, VU-0361737, VU0361737; ML 128; ML-128; ML128
实验参考方法
In Vitro

In vitro activity: VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.


Kinase Assay: VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.

In VivoVU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1).
Animal modelSprague-Dawley rats
Formulation & DosageDissolved in 10% Tween-80; 10 ml/kg; i.p. administration
ReferencesJ Med Chem. 2009 Jul 23;52(14):4115-8; J Med Chem. 2011 Feb 24;54(4):1106-10.