PLGA (75:25) 是一种低毒的，具有生物相容性和生物降解性的药物控释载体，可在生物体内达到缓释的作用。PLGA (75:25) 由 75% 聚乳酸 (PLA) 和 25% 聚乙醇酸 (PGA) 的聚合而成。PLGA (75:25) 已被广泛用于药物、蛋白质和其他各种大分子如 DNA、RNA和肽的输送研究。
| 生物活性 | PLGA (75:25) is a low toxicity, biocompatible and biodegradable controlled drug delivery carrier, can achieve slow release in the organism. PLGA (75:25) is a copolymer of 75% poly lactic acid (PLA) and 25% poly glycolic acid (PGA). PLGA (75:25) has been extensively studied as delivery vehicles for drugs, proteins and various other macromolecules such as DNA, RNA andpeptides[1][2][3]. |
体外研究
(In Vitro) | PLGA (75:25) (0.03-5 mg/mL; 72 h) only affects the viability of Calu-3 cells at concentrations that are too high for clinical use[1].
Cell Viability Assay[1] | Cell Line: | Calu-3 cells | | Concentration: | 0.03-5 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/CS); 3-5 mg/mL (for PLgA (75:25)/CS and PLgA (75:25)/PF68); 0.03-1 mg/mL (for PLgA (75:25)/PVA and PLgA (75:25)/PF68) (CS (chitosan), PF68 and PVA (poly vinyl alcohol) serve as cationic stabilizer) | | Incubation Time: | 72 h | | Result: | Showed low toxicity to cells (cell viability was always higher than 50%) even at the highest concentration tested, when xposured to PLgA (75:25)/PVA, PLgA (75:25)/CS and PLgA (75:25)/PF68 nanoparticles.
Increased cell viability, after short exposure (4 hours) to PLGA/PF68 nanoparticles. |
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体内研究
(In Vivo) | PLGA (75:25) (40 mg/kg Risperidone (PLGA (75:25) as a drug delivery carrier); s.c.; single) shows a good activity of sustained drug release for 45 days[2].
| Animal Model: | Male Sprague-Dawley rats[2]. | | Dosage: | 40 mg/kg (dose of Risperidone, PLGA (75:25) as a drug delivery carrier). | | Administration: | Subcutaneous injection; single. | | Result: | Achieved slow release in vivo: after an initial burst, a sharp drop occurred and the drug levels through day 22 remained in a steady manner while progressing to a decline up to day 45. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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